Mariner Talk Chat Forum

Sibelius Hindemith wrote: ↑

Mon Jun 24, 2024 4:26 am

Maybe we can trade Julio for Spongebob. Would be an upgrade...

Toronto Blue Jays infielder Orelvis Martinez has been suspended for 80 games for violating Major League Baseball's doping policy.

The 22-year-old from the Dominican Republic only made his Major League debut on Friday but has tested positive for clomiphene, a fertility drug on MLB's banned performance-enhancing drugs list.

Martinez said in a statement he was prescribed Rejun 50, which contains clomiphene, by a fertility clinic in his homeland after trying unsuccessfully since 2020 to start a family with his girlfriend.

Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.

Taking testosterone directly is only one way to boost androgen levels; it's also possible to boost testosterone indirectly. That’s what Clomid does.6

Men have estrogen and estrogen receptors, just less than women have. Clomid works by blocking estrogen receptors in the body. When estrogen receptors are blocked, the body doesn't detect the levels of estrogen circulating in the body as it normally would.

This leads the hormone-producing glands to think estrogen levels are low (even though they aren't), and so the glands attempt to produce more estrogen. The body does this by boosting production of two other important reproductive hormones: luteinizing hormone (LH) and follicle stimulating hormone (FSH).

What does this have to do with testosterone? Testosterone is produced by cells known as Leydig cells. They produce testosterone in response to LH. So higher levels of LH mean higher levels of testosterone.

This is how Clomid raises testosterone levels indirectly. The athlete isn’t directly taking additional testosterone, but tricking the body into producing more on its own.

Clomid isn’t the only drug that can be used this way. Others include raloxifene and tamoxifen (Nolvadex). Many of these drugs are prohibited by doping agencies as well.

Captain 97 wrote: ↑

Mon Jun 24, 2024 7:12 pm

From the interwebs....